Courtney Henggeler as Missy Cooper – Then
Sheldon’s fraternal twin sister Missy is entirely distinct from her sibling. Sheldon is anything but friendly and pleasant, despite the fact that she is. When she initially appears, Leonard, Howard, and Raj are all smitten with her.

Sheldon informs them that he will decide who gets to date her as the men fight it out to grab her attention. Each of the guys tries his luck at asking Missy out when they are hanging out at her apartment, but none of them are successful. Missy finds an ally in Penny.
Courtney Henggeler as Missy Cooper – Now
One of Courtney’s earliest acting gigs was on “The Big Bang Theory.” She has since appeared in a few other roles, most of which were supporting ones.

She appeared as Claudia in the popular CBS comedy “Mom” from 2013 to 2015, sharing the screen with Anna Faris and Allison Janney. She started appearing as Amanda LaRusso on a regular basis in the Netflix smash “Cobra Kai” in 2018.
John Ross Bowie as Barry Kripke – Then
Leonard and Sheldon’s colleague Barry Kripke, Ph.D., is a former plasma physicist at Caltech who is now a string theorist. He is incredibly intelligent and also sort of attractive because he has rhotacism, but he can also be annoying and knows precisely how to annoy others.

Nonetheless, he is quite talented and therefore appreciated (even if not entirely liked) by Sheldon, Howard, Leonard, and Raj. He first appeared in the show during season 2 and has kept appearing in later seasons as well.
John Ross Bowie – Now
John is most recognized for his work on TBBT, but he has established a solid reputation for himself elsewhere as well.

He often performs sketch humor and is quite active in the comedy community, both as a writer and performer of sketches. Additionally, he has acted in a number of movies, including “What the Bleep Do We Know” and “He’s Just Not That Into You.”
Wil Wheaton as Wil Wheaton – Then
In the TBBT, Wil Wheaton portrays himself from seasons 1 through 11. He had to portray a more sinister version of himself, which took some acting.

He and Sheldon had some history, but in season 5, they made amends and rekindled their friendship.
Wil Wheaton – Now
It looks like Richard William “Wil” Wheaton III can do everything. He is a voice actor, actor, TV personality, writer, and blogger. In addition to “Eureka,” he has appeared in “Stand By Me,” “Toy Soldiers,” “Legion of Superheroes,” and “Star Trek: The Next Generation.”

In addition to all of this, he is the co-creator and host of the YouTube game-focused online series “TableTop.”
Laurie Metcalf as Mary Cooper – Then
Thank goodness Sheldon Cooper, the genius himself, is still alive for Mary Cooper. Sheldon’s mother is named Mary Cooper.

Sheldon Cooper and Mary Cooper are extremely unlike. Mary is a born-again, devoted Christian who frequently monitors her kid and makes an effort to reason with him (usually following a phone call from Leonard).
Laurie Metcalf – Now
In her long career, Laurie Metcalf has played numerous noteworthy parts on well-known TV series. She has appeared in the films The McCarthy’s, Getting On, Desperate Housewives, and Roseanne.

She is presently repeating her Jackie Harris character in the “The Conners” spinoff of the series due to her participation in “Rosanne.”
Christine Baranski as Dr. Beverly Hofstadter – Then
Dr. Beverly Hofstadter is unmistakably Leonard’s mother because of their shared last name.

Although not all of her sixteen episodes of the program were recorded in the studio due to her character’s attendance occasionally only being necessary through video chat, she has featured in them all. nice job working from home, huh?
Christine Baranski – Now
Like many actors and actresses, Christine attended the esteemed Juilliard School for her education. Her stately, dignified demeanor and voice have had an impact on the performing profession.

Actress Christine Baranski has demonstrated her prowess on both stage and cinema. The two-time Tony winner also acted in the “Mamma Mia” movie and the popular television series “The Good Fight,” and she is continuously engaged in new endeavors.